Jaylen Warren looks like a strong Week 2 start in PPR leagues, nursing a solid floor as a high-end RB2 while sharing work with Kenneth Gainwell. The Steelers’ matchup against Seattle offers a favorable environment, especially if Gainwell continues to struggle with efficiency. Warren’s quick, decisive runs and reception upside give him steady fantasy value, with the potential to push into the top tier of Week 2 backs if the Seattle defense stays vulnerable to both the run and short passes.

If Gainwell falters, Warren could absorb a larger workload and be Pittsburgh’s featured runner, a path that raises his ceiling beyond the typical RB2 range. The combination of Pittsburgh’s backfield dynamics and Seattle’s Week 1 struggles defending backs sets Warren up to deliver solid, usable Week 2 production in most formats.

Buffalo aims to attack New York’s secondary with a precision-heavy passing attack, leveraging Josh Allen’s prime form and Joe Brady’s scheme to maximize yards-after-catch and red-zone efficiency. A fast, clean start in Week 2 would push the Bills to 2-0 and force the Jets into rare mistakes in a divisional bout.

The Bills’ defense seeks a repeat performance against a run-first, mobile offense, even with Ed Oliver sidelined by an ankle injury. Rookie T.J. Sanders steps into a bigger role as Buffalo pressures Zach Wilson and neutralizes the Jets’ ground game, while Buffalo fights for balance and control of pace to dictate the tempo at MetLife.

Key narratives center on Allen’s ability to exploit a vulnerable Jets secondary, the Bills’ offensive efficiency under Brady, and the defense’s capacity to replicate a plan that stifles a multi-faceted attack. If Buffalo can execute with discipline, convert in the red zone, and limit big plays, the Week 2 win can reinforce the AFC East message.